<SEC-DOCUMENT>0001044321-12-000042.txt : 20120213
<SEC-HEADER>0001044321-12-000042.hdr.sgml : 20120213
<ACCEPTANCE-DATETIME>20120213163249
ACCESSION NUMBER:		0001044321-12-000042
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20120213
DATE AS OF CHANGE:		20120213
GROUP MEMBERS:		AUSTIN W. MARXE
GROUP MEMBERS:		AWM INVESTMENT COMPANY, INC.
GROUP MEMBERS:		DAVID M. GREENHOUSE
GROUP MEMBERS:		LS ADVISERS, LLC
GROUP MEMBERS:		SPECIAL SITUATIONS LIFE SCIENCES FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PHARMACYCLICS INC
		CENTRAL INDEX KEY:			0000949699
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943148201
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-46749
		FILM NUMBER:		12599565

	BUSINESS ADDRESS:	
		STREET 1:		PHARMACYCLICS INC
		STREET 2:		995 E ARQUES AVE
		CITY:			SUNNYVALE
		STATE:			CA
		ZIP:			94085-4521
		BUSINESS PHONE:		408 774 0330

	MAIL ADDRESS:	
		STREET 1:		PHARMACYCLICS INC
		STREET 2:		995 E ARQUES AVE
		CITY:			SUNNYVALE
		STATE:			CA
		ZIP:			94085-4521

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MARXE AUSTIN W & GREENHOUSE DAVID M
		CENTRAL INDEX KEY:			0001044321
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		C/O SPECIAL SITUATIONS FUNDS
		STREET 2:		527 MADISON AVENUE, SUITE 2600
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		2122076500

	MAIL ADDRESS:	
		STREET 1:		C/O SPECIAL SITUATIONS FUNDS
		STREET 2:		527 MADISON AVENUE, SUITE 2600
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>pharmacyclics13gt.txt
<DESCRIPTION>PHARMACYCLICS, INC. 13G
<TEXT>
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
				       (Amendment No. __)

Pharmacyclics, Inc.
                  _____________________________________________
       (Name of Issuer)

Common Stock
                  _______________________________________________
(Title of Class of Securities)

716933106
                 _________________________________________________
(CUSIP Number)


		with a copy to:
Austin W. Marxe		Allen B. Levithan, Esq.
527 Madison Avenue, Suite 2600		Lowenstein Sandler PC
New York, New York 10022		65 Livingston Avenue
			Roseland, New Jersey 07068
			(973) 597-2406
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

December 31, 2011
 (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

	____	Rule 13d-1(b)
	_x__	Rule 13d-1(c)
	____	Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed
 to be ?filed? for the purpose of Section 18 of the Securities Exchange Act of
 1934 (?Act?) or otherwise subject to the liabilities of that section of the
Act
 but shall be subject to all other provisions of the Act (however, see the
Notes).


Cusip No. 716933106       13G                           Page 2 of 6 Pages
1.Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
(entities only):

	Austin W. Marxe and David M. Greenhouse

2.	Check the Appropriate Box if a Member of a Group (See Instructions):
	(a)	[    ]	 	Not Applicable
	(b)	[    ]

	3.	SEC Use Only

	4.	Source of Funds (See Instructions):  00

	5.	Check if Disclosure of Legal Proceedings Is Required Pursuant to
Items 2(d) or 2(e):
				Not Applicable

	6.	Citizenship or Place of Organization:	    United States

	Number of	7.	Sole Voting Power:	0
	Shares Beneficially	8.	Shared Voting Power:	254,475*
	Owned by
	Each Reporting	9.	Sole Dispositive Power:	0
	Person With	10.	Shared Dispositive Power: 254,475*____

	11.	Aggregate Amount Beneficially Owned by Each Reporting Person:
         254,475*

	12.	Check if the Aggregate Amount in Row (11) Excludes Certain Shares
		(See Instructions):		               Not Applicable

	13.	Percent of Class Represented by Amount in Row (11):     5.4%*

	14.	Type of Reporting Person (See Instructions):       IA, IN


* This is a joint filing by Austin W. Marxe (?Marxe?) and David M. Greenhouse
(?Greenhouse?).  Marxe and Greenhouse share sole voting and investment power
over 254,475 shares of Common Stock owned by Special Situations Life Sciences
Fund, L.P. See Items 2 and 4 of this Schedule for additional information.


								Page 3 of 6 Pages
Item 1.	Security and Issuer:
	(a) Pharmacyclics, Inc.
	(b) 995 E. Arques Avenue, Sunnyvale, CA 94085

Item 2. (a)	Name of Person Filing:
	The persons filing this report are Austin W. Marxe (?Marxe?) and
David M. Greenhouse (?Greenhouse?), who are the controlling principals of AWM
Investment Company, Inc. (?AWM?). Marxe and Greenhouse are also members of LS
Advisers L.L.C. (?LS?), the general partner of Special Situations Life
Sciences Fund, L.P. (?SSLS?).    AWM serves as the investment adviser to SSLS.
(SSLS will hereafter be referred to as, the ?Fund?).  The principal business
of each Fund is to invest in equity and equity-related securities and other
securities of any kind or nature.

             (b) Address of Principal Business Office or, if none, Residence:

	The principal business address for Marxe and Greenhouse is 527
Madison Avenue, Suite 2600, New York, NY  10022.


              (c) Citizenship:

       	           Austin W. Marxe and David M. Greenhouse are United
States citizens.

              (d) Title of Class of Securities:  Common Stock
	              (e) CUSIP Number:  716933106.

Item 3.     If this statement is filed pursuant to $240.13d-1(b) or 240.13d-
2(b), check whether
            the person filing is a:    Not Applicable

(a) ( )	Broker or Dealer registered under section 15 of the Act;
(b) ( )	Bank as defined in section 3(a) (6) of the Act;
(c) ( )	Insurance Company as defined in section 3(a) (19) of the Act;
(d) ( )	Investment Company registered under section 8 of the Investment
Company Act of 1940;
(e) ( )	An Investment Adviser in accordance with $240.13d
		-1(b)(I)(ii)(E);
(f) ( )	An employee benefit plan or endowment fund in accordance with
$240.13d-1(b)(I)(ii)(F);


								Page 4 of 6 Pages

(g) ( )	A parent holding company or control person in accordance with
$240.13d-
	1(b)(1)(ii)(G);
(h) ( ) 	A savings association as defined in Section 3(b) of the Federal
Deposit Insurance

	Act;
(i) ( ) 	A church plan that is excluded from the definition of an
investment company under section 3(c)(14) of the Investment
Company Act of 1940;
(j) ( )   	Group, in accordance with $240.13d-1(b)(1)(ii)(J).


Item 4.       Ownership:

	 (a) Amount Beneficially Owned:  Messrs. Marxe and Greenhouse
beneficially own a total of 254,475 shares of Common Stock. This amount
includes 254,475 shares of Common Stock owned by SSLS.

	(b) Percent of Class:  Messrs. Marxe and Greenhouse beneficially own
5.4% of the shares outstanding, of which, SSLS owns 5.4% of the outstanding
shares.

	(c) Number of Shares as to which the person has:

		(i)	Sole power to vote or to direct the vote:  0

		(ii)	Shared power to vote or to direct the vote:  254,475
		(iii)	Sole power to dispose or to direct the disposition of:  0

(iv)	Shared power to dispose or to direct the disposition of:
254,475


Item 5. Ownership of Five Percent or Less of a Class:  If this statement is
being filed to report the fact that as of the date hereof the reporting person
has ceased to be the beneficial owner of more that five percent of the class
of securities, check the following __.

Item 6.Ownership of More than Five Percent on Behalf of Another Person:  Not
Applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security being Reported on By the Parent Holding Company:  Not Applicable.

Item 8. Identification and Classification of Members of the Group:  Not
applicable

Item 9. Notices of Dissolution of Group:  Not applicable.


								Page 5 of 6 Pages

Item 10.Certification:

	By signing below I certify that, to the best of my knowledge and belief,
the securities
referred to above were acquired and are held in the ordinary course of
business and were not
acquired and are not held for the purpose of or with the effect of changing or
influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with
or as a participant in any transaction having that purpose or effect.


SIGNATURE


	After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: February 13, 2012


				/s/ Austin W. Marxe
				AUSTIN W. MARXE


				/s/David M Greenhouse
				DAVID M. GREENHOUSE


Attention:  Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001).


       								Page 6 of 6 Pages


JOINT FILING AGREEMENT


	Austin W. Marxe and David M. Greenhouse hereby agree that the Schedule
13G to which this agreement is attached is filed on behalf of each of them.


	/s/_Austin W. Marxe
Austin W. Marxe


	/s/_David M. Greenhouse
David M. Greenhouse


-6-

S5313/1
1319328.02
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>